GcMAF Therapy for Autism

GcMAF Therapy for Autism

Autism Spectrum Disorders (ASD)

Autism Spectrum Disorders (ASD) are neurodevelopmental diseases characterized by impaired social interaction, repetitive behaviors, and deficient language and social skills.

Reports of autism cases per 1,000 children grew dramatically in the US from 1996 to 2007.

The rapid increase in the number of autism cases in such a short period of time suggests that environmental factors are responsible for or a significant contributing factor in these types of diseases. However, complexity arises due to interactions among multiple genes, the environment and epigenetic factors which do not change DNA but are heritable and influence gene expression. Chart source Wikipedia.



Conventional management of Autism

More than half of US children diagnosed with ASD are prescribed psychoactive drugs or anticonvulsants, with the most common drug classes being antidepressants, stimulants, and antipsychotics. Aside from antipsychotics, there is scant reliable research about the effectiveness or safety of drug treatments for adolescents and adults with ASD. A person with autism may respond atypically to medications, the medications can have adverse effects, and no known medication relieves autism’s core symptoms of social and communication impairments.

So essentially, conventional management of Autism does not address the cause of the disease and only attempts to treat the symptoms.



The immune system and Autism

Recently it is becoming clear that immune system disfunction plays an important role in autism.

Altered immunity in individuals with Autism

Immunological abnormalities involving cytokines, immunoglobulins, inflammation and cellular activation have been noted in individuals with autism.

Alterations in various immune cells including Natural Killer Cells and Macrophages have also been observed in individuals with autism. Upon stimulation, NK cells from individuals with autism showed diminished cytotoxic activity.

Macrophage migration inhibitory factor (MIF or MMIF)

A cytokine recently linked to autism is macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory immune regulator that is constitutively expressed in brain tissues, and has important influences on neural and endocrine systems. This macrophage migration inhibitory factor cytokine is produced by neuroendocrine and immune tissues. Macrophage migration inhibitory factor possesses glucocorticoid-antagonist properties within the immune system and participates in the regulation of several endocrine circuits.

  • Plasma levels of macrophage migration inhibitory factor (MIF) were higher in individuals with autism.
  • Individuals with autism with the highest levels of plasma MIF were found to have the most severe behavioral symptoms.
  • Macrophage migration inhibitory factor is of critical importance for the host response to microbial infections and in several autoimmune diseases.
  • Macrophage migration inhibitory factor expression is usually constitutive at low levels.

Immunoglobulin Levels

  • Decreased levels of total plasma IgG and IgM have been observed in a large group of individuals with autism.
  • The reduced levels correlated with behavior, such that individuals with autism with the most severe behavioral symptom scores had the lowest IgG and IgM levels.

Altered sensitivity to environmental toxicants – PBDEs, immunity and autism

A complex interplay between immunological and environmental factors may have a role in autism. Polybrominated diphenyl ethers (PBDEs) are environmental toxicants that impact neurodevelopment and immunity. Individuals with ASD have different immune sensitivity to the environmental toxicant



GcMAF therapy for the treatment of Autism

Second Generation High Dose GcMAF immunotherapy is administered to overcome the problem of immune system disfunction, including that of macrophage migration inhibitory factor (MIF), which plays an integral role in autism and leads to commonly observed symptoms.


    • Recommended dose – 0.25ml High Dose GcMAF, twice weekly by intramuscular or subcutaneous injection. *
  • Some improvements in symptoms should be observed within 2 months.
  • Minimum treatment course of 6 months should be expected, but each individual patient is different and additional courses may be required based on positive progress.
  • Patients may need longer term maintenance doses of GcMAF therapy to stay well and symptom free until their immune system is fully developed enough to cope with challenges.

* These dosage recommendations apply only to Saisei Mirai Second Generation GcMAF.

If you wish to purchase GcMAF therapy or make an enquiry, please contact us with details of your disease, current treatment and the quantities of Gc-MAF you require.


Goines P, Van de Water J. The immune system’s role in the biology of autism. Current Opinion in Neurology (2010) 23(2):111-7. Fingerle-Rowson GR, Bucala R. Neuroendocrine properties of macrophage migration inhibitory factor (MIF). Immunology and Cell Biology (2001) 79:368–375

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