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The Cellular Blueprint for Slowing Aging
At Saisei, we believe aging is not just a natural process, but a treatable condition. The key lies in telomeres—the protective caps at the ends of our chromosomes—and in powerful longevity-related genes like Klotho. As telomeres shorten with each cell division, cellular function declines, accelerating the aging process. Meanwhile, Klotho, often called the "longevity gene," plays a vital role in reducing oxidative stress, regulating inflammation, and supporting cellular repair. Through immune rejuvenation, telomere preservation, and enhanced Klotho expression, we are pioneering a new path toward extending both healthspan and lifespan.
Unlock the Future of Anti-Aging with Dietary MAF
Early clinical findings from a Phase 2 study in Japan suggest that Dietary MAF may help support key markers associated with healthy aging. In a group of adults aged 40 and above, participants experienced an average 23% increase in telomere length after six months, along with increases in telomerase activity and the longevity-related protein α-Klotho.
Developed by Saisei Pharma, Dietary MAF is designed to support immune function, cellular repair, and overall vitality. While research is ongoing, these initial results highlight its potential as a food-based approach to promoting cellular rejuvenation and long-term wellness.
Experience a science-informed path toward healthier aging.
A New Era of Dietary Rejuvenation: Phase 2 Clinical Trial of Dietary MAF in Japan
A New Era of Dietary Rejuvenation: Phase 2 Clinical Trial of Dietary MAF in Japan
Boosting Klotho with MAF TripleProtecting Klotho May Be Key to Healthy Longevity
A groundbreaking experiment showed that dietary MAF significantly increased α-Klotho levels in mice.
✅ Plasma α-Klotho levels: Nearly doubled compared to water and whey protein groups.
✅ Brain (Hypothalamus & Amygdala): Markedly increased α-Klotho content.
✅ Kidney: Strongest α-Klotho increase—vital since kidneys produce ~80% of circulating α-Klotho.
8-day test | 60 μg/ml whey protein in water | Measured via ELISA
This research highlights MAF’s powerful potential in supporting anti-aging and longevity.
Effects of MAF on Plasma α-Klotho levels in humans (pg/ml)
This graph illustrates how MAF supplementation influences plasma α-Klotho levels in humans.
As shown, α-Klotho levels increased by approximately 20% after 3 and 6 months of taking MAF Triple, indicating a sustained improvement over time.
Degalactosylated Whey Protein (D-WP) Study – Effects on Telomere Length in Mice
A separate experimental study examined the effects of D-WP on telomere length and telomerase gene expression in young and aged mice.
📌 Findings:
✔ D-WP increased telomere length by 154% in young mice, while regular whey protein (WP) showed only a 121% increase.
✔ D-WP significantly upregulated telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) gene expression in peripheral blood.
✔ In aged mice, D-WP restored telomere length to youthful levels.
📌 Implication: D-WP, a key component in MAF Triple, enhances telomere maintenance, supporting longevity and cellular health.
🔗 Access the full study: Scientific Reports (2024)
Featured in Nature
Our advertisement feature, Could immune proteins have anti-ageing benefits?, was published on 13 March 2025, as part of Focal Point on Ageing in Japan in the online version of Nature, a weekly international journal publishing the finest peer-reviewed research in science and technology.
The advertisement feature can be found here: https://www.nature.com/articles/d42473-024-00361-3
Telomere Research by Saisei Mirai Featured in Science Featured
We are pleased to share that Dr. Toshio Inui, CEO of Saisei Mirai Clinics Group, has been featured in the respected international science publication Science Featured for his pioneering research on telomere lengthening.
The article, titled Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice, was published on April 16, 2025.
This recognition highlights our ongoing commitment to advancing evidence-based innovation in telomere biology, longevity science, and immune health.
Explore articles and more on our blog
Keep up to date with the latest news on Saisei Group research, clinical trials, and Dietary MAF products.
Featured on Nature: Our Latest Article on Nutrition & Longevity
Saisei Mirai’s latest article is now published on Nature.com as part of the Spotlight Nutrition feature. We are pleased to...
A New Era of Dietary Rejuvenation: Phase 2 Clinical Trial of Dietary MAF in Japan
The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable...
Saisei Medical Conference 2025
📍 Osaka International Convention Center,📅 Saturday, November 8, 2025 | 10:00 AM – 5:00 PM A Global Gathering in Osaka This...
Featured on Nature: Our Latest Article on Nutrition & Longevity
Saisei Mirai’s latest article is now published on Nature.com as part of the Spotlight Nutrition feature. We are pleased to...
A New Era of Dietary Rejuvenation: Phase 2 Clinical Trial of Dietary MAF in Japan
The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable...
Saisei Medical Conference 2025
📍 Osaka International Convention Center,📅 Saturday, November 8, 2025 | 10:00 AM – 5:00 PM A Global Gathering in Osaka This...
Dietary MAF (Superfood)
Dietary MAF (Macrophage Activating Factor) Series boosts the immunity by activating the immune cells without any side effects. Stay young and healthy by taking these anti-aging supplements.
Free of
Wheat, soy, egg, rice, gluten, starch, sugar*, hormones, antibiotics, preservatives, artificial sweeteners, artificial colors. *Sugar is contained in M-Lollies
Topical and Oral
MAF is available in both topical and oral supplement forms. The 4 types of MAF products allows MAF to be absorbed from the mouth, intestines and the skin. The MAF Series is made exclusively with natural ingredients.
Uniqueness
MAF was developed using our own unique patented method. MAF helps boost the immune system by activating macrophages without any side effects.
Factory in Japan
MAF Series is produced in our Saisei Mirai GMP factory in Moriguchi, Osaka. The factory is certified by the Ministry of Health, Labor and Welfare of Japan.
Targets everyday wellness; naturally and safely
Dietary MAF is approved as "Health Food" in Japan and in some European countries.
Saisei Pharma’s immune activating food products are safe and made exclusively from natural ingredients.