The Foundation of Cellular Longevity
Aging begins deep within our cells. Telomere shortening, immune decline, and reduced expression of longevity-associated genes such as Klotho all contribute to the gradual changes we experience over time.
At Saisei Hawaii, we support healthy aging through Dietary MAF, created using Saisei Mirai’s patented food-based formulation technology.
This specialized approach is designed to support immune balance and help maintain the cellular functions associated with long-term wellness.
Recent clinical research in Japan has shown encouraging connections between Dietary MAF and key biomarkers related to biological aging.
Why Telomeres and Klotho Matter
Healthy aging is shaped not only by years of life, but by the condition of our cells.
Cellular Aging and Immune Decline
As we age, immune efficiency gradually decreases while low-grade inflammation tends to rise. This process—often called “inflammaging”—can accelerate biological aging, disrupt tissue repair, and influence gene expression linked to longevity.
A Gentle, Daily Approach
Food-based support that works with the body’s natural systems may offer a sustainable way to maintain cellular vitality over time.
Telomeres — Protectors of Your Genetic Blueprint
Telomeres are protective caps located at the ends of chromosomes. With each cell division, telomeres shorten. When they become too short, cells lose their ability to repair, regenerate, or function effectively.
Why Telomere Length Matters
- Shorter telomeres are associated with accelerated biological aging
- Telomere length correlates with immune strength and cellular resilience
- Supporting telomere integrity is a major focus within longevity science
Telomerase (TERT & TERC)
Telomerase helps rebuild telomeres, but its activity is typically low in adulthood. A balanced internal environment may help support healthier telomerase-related activity.
Klotho —The Longevity-Associated Gene
Klotho is a well-studied protein involved in:
- Cognitive support
- Kidney and metabolic health
- Anti-inflammatory regulation
- Cellular protection and resilience
Klotho levels naturally decline with age. Higher expression is associated with healthier aging, making it a central marker in longevity research.
The Role of Macrophages
Macrophages contribute to:
- Managing inflammation
- Supporting tissue repair
- Maintaining immune communication
- Influencing cellular signaling related to aging
By supporting balanced macrophage function, Dietary MAF may help maintain the internal conditions linked to healthier telomere dynamics, improved cellular balance, and favorable longevity-related gene expression.
This support occurs through nutritional pathways — not pharmaceutical mechanisms — making MAF suitable for long-term daily use.
Clinical Evidence: Phase 2 Study in Japan (2024–2025)
A multicenter observational Phase 2 study evaluated the effects of Dietary MAF on biomarkers of aging in 203 adults aged 40 and older over six months.
Biomarkers Assessed
- Telomere length
- Telomerase-related genes (TERT, TERC)
- Klotho blood levels
- DNA methylation–based biological age
Key Findings (161 evaluated participants)
Telomere Length
- +12% increase after 3 months
- +23% increase after 6 months
Klotho Levels
- +20% increase at both 3 and 6 months
Biological Age
- –1.35 years reduction in a 60-person subgroup
Telomerase Activity
- Favorable upward trends in TERT and TERC
Important Notes
- Non-randomized; no placebo control
- Results are preliminary and individual results may vary
- Further controlled studies are planned
Dietary MAF is not a medical treatment, yet these findings suggest potential value in supporting pathways associated with cellular longevity.
What These Findings Suggest
Improvements in telomere-related markers, increases in Klotho, and supportive immune activity highlight the potential of our patented food-based formulation technology to influence key biological aging markers.
This gentle, sustainable approach may help support:
- Cellular maintenance and repair
- Immune balance
- Healthy aging processes
- Overall resilience against age-related decline
Dietary MAF is ideal for individuals seeking long-term wellness support through food-derived technologies.
Picture: Dr. Toshio Inui, CEO of Saisei Group
MAF Boosts Longevity Protein α-Klotho!
A groundbreaking experiment by Dr. Katuura (formerly Kagoshima University, now at Saisei Mirai) showed that dietary MAF significantly increased α-Klotho levels in mice.
✅ Plasma α-Klotho levels: Nearly doubled compared to water and whey protein groups.
✅ Brain (Hypothalamus & Amygdala): Markedly increased α-Klotho content.
✅ Kidney: Strongest α-Klotho increase—vital since kidneys produce ~80% of circulating α-Klotho.
8-day test | 60 μg/ml whey protein in water | Measured via ELISA
This research highlights MAF’s powerful potential in supporting anti-aging and longevity.
Unlocking the Secrets of Telomeres & Aging
Degalactosylated Whey Protein (D-WP) Study – Effects on Telomere Length in Mice
A separate experimental study examined the effects of D-WP on telomere length and telomerase gene expression in young and aged mice.
📌 Findings:
✔ D-WP increased telomere length by 154% in young mice, while regular whey protein (WP) showed only a 121% increase.
✔ D-WP significantly upregulated telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) gene expression in peripheral blood.
✔ In aged mice, D-WP restored telomere length to youthful levels.
📌 Implication: D-WP, a key component in MAF Triple, enhances telomere maintenance, supporting longevity and cellular health.
🔗 Access the full study: Scientific Reports (2024)
The Science of Aging – How Does It Work?
Aging isn’t just about time—it’s a biological process driven by molecular changes, particularly:
📌 Telomere Shortening – Limits cell division, leading to tissue degeneration and organ decline.
📌DNA Methylation Alterations – Epigenetic changes that influence gene activity, driving aging and disease.
📌Oxidative Stress & Chronic Inflammation – Accelerate cellular damage and tissue aging.
Begin Your Cellular Longevity Journey
Support your body’s natural pathways for vitality, balance, and long-term cellular health — every day.
Explore our Dietary MAF formulations →
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