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The Cellular Blueprint for Slowing Aging
At Saisei, we believe aging is not just a natural process, but a treatable condition. The key lies in telomeres—the protective caps at the ends of our chromosomes—and in powerful longevity-related genes like Klotho. As telomeres shorten with each cell division, cellular function declines, accelerating the aging process. Meanwhile, Klotho, often called the "longevity gene," plays a vital role in reducing oxidative stress, regulating inflammation, and supporting cellular repair. Through immune rejuvenation, telomere preservation, and enhanced Klotho expression, we are pioneering a new path toward extending both healthspan and lifespan.
Unlock the Future of Anti-Aging with Dietary MAF
Clinically proven to extend telomeres by 23% in just six months, Dietary MAF by Saisei Pharma is at the forefront of longevity science. Developed to support immune strength, tissue repair, and cellular rejuvenation, this breakthrough supplement helps you look up to 20 years younger and live vibrantly beyond 100. Experience science-backed vitality—aging redefined.
Analysis of the effect of taking MAF capsules on telomere length changes
Boosting Klotho with MAF TripleProtecting Klotho May Be Key to Healthy Longevity
A groundbreaking experiment showed that dietary MAF significantly increased α-Klotho levels in mice.
✅ Plasma α-Klotho levels: Nearly doubled compared to water and whey protein groups.
✅ Brain (Hypothalamus & Amygdala): Markedly increased α-Klotho content.
✅ Kidney: Strongest α-Klotho increase—vital since kidneys produce ~80% of circulating α-Klotho.
8-day test | 60 μg/ml whey protein in water | Measured via ELISA
This research highlights MAF’s powerful potential in supporting anti-aging and longevity.
Degalactosylated Whey Protein (D-WP) Study – Effects on Telomere Length in Mice
A separate experimental study examined the effects of D-WP on telomere length and telomerase gene expression in young and aged mice.
📌 Findings:
✔ D-WP increased telomere length by 154% in young mice, while regular whey protein (WP) showed only a 121% increase.
✔ D-WP significantly upregulated telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) gene expression in peripheral blood.
✔ In aged mice, D-WP restored telomere length to youthful levels.
📌 Implication: D-WP, a key component in MAF Triple, enhances telomere maintenance, supporting longevity and cellular health.
🔗 Access the full study: Scientific Reports (2024)
Featured in Nature
Our advertisement feature, Could immune proteins have anti-ageing benefits?, was published on 13 March 2025, as part of Focal Point on Ageing in Japan in the online version of Nature, a weekly international journal publishing the finest peer-reviewed research in science and technology.
The advertisement feature can be found here: https://www.nature.com/articles/d42473-024-00361-3
Telomere Research by Saisei Mirai Featured in Science Featured
We are pleased to share that Dr. Toshio Inui, CEO of Saisei Mirai Clinics Group, has been featured in the respected international science publication Science Featured for his pioneering research on telomere lengthening.
The article, titled Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice, was published on April 16, 2025.
This recognition highlights our ongoing commitment to advancing evidence-based innovation in telomere biology, longevity science, and immune health.
Explore articles and more on our blog
Keep up to date with the latest news on Saisei Group research, clinical trials, and Dietary MAF products.
Saisei Mirai Featured in Science Featured – Telomere Research Recognized
Dr. Inui’s research on telomere length and aging has been featured in Science Featured, recognizing Saisei Mirai’s contributions to longevity...
Anti-Aging Conference 2025 – Now Available On-Demand
The Anti-Aging Conference 2025 has concluded successfully. Full recordings are now available to watch online, featuring expert talks on longevity...
Saisei Mirai Clinics Anti-Aging Conference 2025 Osaka
Theme: Reversing Biological Age – Rejuvenation Join us for an exciting full-day conference dedicated to the most advanced therapies and...
Saisei Mirai Featured in Science Featured – Telomere Research Recognized
Dr. Inui’s research on telomere length and aging has been featured in Science Featured, recognizing Saisei Mirai’s contributions to longevity and regenerative medicine.
Anti-Aging Conference 2025 – Now Available On-Demand
The Anti-Aging Conference 2025 has concluded successfully. Full recordings are now available to watch online, featuring expert talks on longevity and biological age reversal.
Saisei Mirai Clinics Anti-Aging Conference 2025 Osaka
Theme: Reversing Biological Age – Rejuvenation Join us for an exciting full-day conference dedicated to the most advanced therapies and...
6 Effects of MAF
Dietary MAF (Superfood)
Dietary MAF (Macrophage Activating Factor) Series boosts the immunity by activating the immune cells without any side effects. Stay young and healthy by taking these anti-aging supplements.
Free of
Wheat, soy, egg, rice, gluten, starch, sugar*, hormones, antibiotics, preservatives, artificial sweeteners, artificial colors. *Sugar is contained in M-Lollies
Topical and Oral
MAF is available in both topical and oral supplement forms. The 4 types of MAF products allows MAF to be absorbed from the mouth, intestines and the skin. The MAF Series is made exclusively with natural ingredients.
Uniqueness
MAF was developed using our own unique patented method. MAF helps boost the immune system by activating macrophages without any side effects.
Factory in Japan
MAF Series is produced in our Saisei Mirai GMP factory in Moriguchi, Osaka. The factory is certified by the Ministry of Health, Labor and Welfare of Japan.
Targets everyday wellness; naturally and safely
Dietary MAF is approved as "Health Food" in Japan and in some European countries.
Saisei Pharma’s immune activating food products are safe and made exclusively from natural ingredients.