The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable signs of biological aging.
One emerging approach attracting scientific attention is MAF (Macrophage Activating Factor) delivered through diet. In Japan, a large-scale clinical trial is underway to investigate whether Dietary MAF can meaningfully influence markers of aging and longevity.
This article highlights the latest findings from the ongoing Phase 2 study.
Study Overview: 203 Adults Aged 40+ Participated
This multi-center, non-randomized Phase 2 interventional trial involved 203 healthy adults over 40 years old—139 females and 64 males—ranging from their 40s to their 90s.
Primary Objective
- Evaluate the efficacy of Dietary MAF on rejuvenation and longevity
Secondary Objectives
- Telomere length measurement
- DNA methylation analysis
- Age-related gene expression profiling
Blood samples were collected at baseline, 3 months, and 6 months.
Participants were ordinary adults with no serious illnesses; individuals with cancer, severe diseases, severe allergies, or pregnancy were excluded.
MAF Increased Telomere Length: +12% at 3 Months, +23% at 6 Months
One of the most remarkable findings was the significant change in telomere length:
- 12% increase after 3 months
- 23% increase after 6 months (based on 161 participants)
Telomeres—often described as “the biological clock of cells”—typically shorten with age. A measurable lengthening of telomeres in adults is extremely rare, making these results especially notable.
Additionally, Dietary MAF upregulated telomerase components TERT and TERC, the enzymes responsible for telomere extension.
Long-Life Factor α-Klotho Increased by 20%
The long-recognized anti-aging protein α-Klotho also showed a substantial increase.
On average, plasma α-Klotho levels rose by 20% at both 3 and 6 months.
Animal studies cited in the report also demonstrated increased α-Klotho levels in the brain and kidneys, suggesting systemic anti-aging effects.
Biological Age Reduced by 1.35 Years (in a Subgroup of 60 Participants)
In a subset of 60 participants who exhibited particularly strong telomere extension, the analysis revealed:
An average reduction of 1.35 years in biological age
Biological age reflects the internal aging process of the body, distinct from chronological age.
A reversal of over a year within a few months through dietary intervention indicates promising potential.
What These Findings Suggest
The data from this Phase 2 trial point to several important possibilities:
- Maintenance and extension of telomeres
- Activation of telomerase (TERT/TERC)
- Increased α-Klotho, a key longevity factor
- Potential slowing—or reversal—of biological aging
- A practical, food-based method for supporting healthier aging
While further controlled studies will be essential, the results highlight a compelling vision of the future:
A world where aging can be influenced through diet.
Conclusion
- Dietary MAF showed a significant increase in telomere length, telomerase activity, and α-Klotho levels
- A subgroup analysis showed biological age reduction of 1.35 years
- These findings support the potential for diet-based interventions to impact aging at the cellular and molecular level
As aging research rapidly advances worldwide, interventions like Dietary MAF may soon reshape how we approach health, longevity, and daily nutrition.
