BLOG — Clinical Trial

Cytokine production of mice peritoneal macrophages   IL-1β and TNF-α are major inflammatory cytokines associated with autoimmune diseases.Our Oral MAF does not result in the production of these pro-inflammatory cytokines.   Th2 cytokinesColostrum MAF experiments in healthy dogs   This experiment was conducted by Dr Osaki at Tottori university.In this preliminary experiment, Colostrum MAF induced elevated levels of helper T cells and killer T cells in healthy dogs.   In this preliminary experiment, Colostrum MAF suppressed the production of Interleukin-4 (IL-4) and Interleukin-6 (IL-6). These Th2 cytokines are associated with allergic diseases.  

In June 2020 we applied to the COVID-19 Scientific Technical Triage of the US FDA for the evaluation of the rationale to study the efficacy of MAF Capsules in COVID-19 treatment.   In June 2020 we applied to the COVID-19 Scientific Technical Triage of the US FDA for the evaluation of the rationale to study the efficacy of MAF Capsules in COVID-19 treatment. The US FDA in PreIND 151946 meeting response recommended a small proof of concept (POC) study as the initial step prior to the large-scale trial be run. The US FDA indicated recommendations including the major study endpoints addressing the...