BLOG — Clinical Trial

The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable signs of biological aging.One emerging approach attracting scientific attention is MAF (Macrophage Activating Factor) delivered through diet. In Japan, a large-scale clinical trial is underway to investigate whether Dietary MAF can meaningfully influence markers of aging and longevity. This article highlights the latest findings from the ongoing Phase 2 study. Study Overview: 203 Adults Aged 40+ Participated This multi-center, non-randomized Phase 2 interventional trial involved 203 healthy adults over 40 years old—139 females and 64 males—ranging from their 40s to...

Dr. Inui’s research on telomere length and aging has been featured in Science Featured, recognizing Saisei Mirai’s contributions to longevity and regenerative medicine.

Abstract Background: Age, genetic, and environmental factors are noted to contribute to dementia risk. Neuroplasticity, protection from degeneration and cell death, and early intervention are desirable for preventing dementia. The linkage between neurons and microglia has been a research focus. In this study, we examined the effects of dietary modification (a reduction in advanced glycation end products [AGEs]) and macrophage-activating factor (MAF; a macrophage regulator) supplementation on cognitive function in elderly participants undergoing rehabilitation. Methods: Participants were older than 60 years of age and had been attending a daycare rehabilitation facility for at least three months without cognitive dysfunction, severe...

Abstract The effects of degalactosylated whey protein on lipopolysaccharide (LPS)-induced inflammatory responses in mice were observed in comparison with intact whey protein. Intraperitoneal administration of both intact and degalactosylated whey proteins for 5 days did not affect body weight and food intake in mice. On day 6, intraperitoneal administration of LPS induced a marked decrease in body weight 4 h later. The LPS-induced decrease in body weight was significantly suppressed by the administration of degalactosylated whey protein, but not intact whey protein. Administration of LPS also significantly increase plasma tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels, which were significantly...