Research Hub

Saisei Mirai’s latest article is now published on Nature.com as part of the Spotlight Nutrition feature. We are pleased to share that our latest article,“Exploring Links Between Nutrition and Longevity”,has been published on Nature.com as a featured partner-content article. This article highlights our ongoing work at Saisei Mirai, focusing on how nutrition and immune pathways may play a role in healthy ageing.   The feature explores key areas of our research, including: The relationship between macrophage activation and muscle health Signals such as IGF-1 and their relevance to ageing biology Emerging insights into telomere length and cellular ageing The potential...

The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable signs of biological aging.One emerging approach attracting scientific attention is MAF (Macrophage Activating Factor) delivered through diet. In Japan, a large-scale clinical trial is underway to investigate whether Dietary MAF can meaningfully influence markers of aging and longevity. This article highlights the latest findings from the ongoing Phase 2 study. Study Overview: 203 Adults Aged 40+ Participated This multi-center, non-randomized Phase 2 interventional trial involved 203 healthy adults over 40 years old—139 females and 64 males—ranging from their 40s to...

We can't reveal the exact details yet, but here's a little sneak peek!  The change over time shows a clear increase in telomere length with continued MAF capsule consumption.Based on a 0-month baseline, telomere length increased by approximately 12% at 3 months and 23% at 6 months.Telomeres are crucial structures that play a significant role in cellular health and longevity. They are repetitive DNA sequences located at the ends of chromosomes, acting as protective caps to prevent the loss of important genetic information during cell division.Telomere shortening has been linked to the aging process and age-related diseases. It's often considered a...

Cytokine production of mice peritoneal macrophages   IL-1β and TNF-α are major inflammatory cytokines associated with autoimmune diseases.Our Oral MAF does not result in the production of these pro-inflammatory cytokines.   Th2 cytokinesColostrum MAF experiments in healthy dogs   This experiment was conducted by Dr Osaki at Tottori university.In this preliminary experiment, Colostrum MAF induced elevated levels of helper T cells and killer T cells in healthy dogs.   In this preliminary experiment, Colostrum MAF suppressed the production of Interleukin-4 (IL-4) and Interleukin-6 (IL-6). These Th2 cytokines are associated with allergic diseases.