September 02, 2026

What Is Inflammaging? How the Immune System Changes With Age

Inflammaging describes the persistent, low-level inflammatory activity associated with aging. Discover how it connects with imm...

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August 19, 2026

What Is Chronic Inflammation? Why Immune Balance Matters for Healthy Aging

Inflammation protects the body, but it should settle once its work is complete. Discover how chronic inflammation, macrophages,...

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July 09, 2026

What Are Macrophages? Why They Matter for Healthy Immunity

Learn what macrophages are, how they help maintain immune balance, regulate inflammation, and support healthy immunity. Discove...

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June 18, 2026

Immune Balance vs. Immune Boosting: What’s the Difference?

Immune wellness is not about keeping the immune system permanently stimulated. Learn how Saisei Hawaii explains immune balance,...

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June 09, 2026

Our Article Has Been Accepted for Publication in Frontiers in Nutrition

Big news! Our article has been accepted for publication in Frontiers in Nutrition. Thank you to our co-authors, collaborators, ...

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June 07, 2026

What Is MAF? A Simple Guide to Immune Balance and Healthy Aging

MAF stands for Macrophage Activating Factor. Learn how Saisei Hawaii frames MAF in relation to immune balance, daily wellness, ...

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March 16, 2026

Featured on Nature: Our Latest Article on Nutrition & Longevity

Saisei Mirai’s latest article is now published on Nature.com as part of the Spotlight Nutrition feature. We are pleased to shar...

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December 01, 2025

A New Era of Dietary Rejuvenation: Phase 2 Clinical Trial of Dietary MAF in Japan

The desire to live longer—and live well—is universal. Yet as we age, our cells and genes gradually change, revealing measurable...

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July 27, 2023

Analysis of the effect of taking MAF capsules on telomere length changes　-Challenge to Longevity -

We can't reveal the exact details yet, but here's a little sneak peek!  The change over time shows a clear increase in telomere...

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December 05, 2022

Th2 cytokines- Oral MAF

Cytokine production of mice peritoneal macrophages   IL-1β and TNF-α are major inflammatory cytokines associated with autoimm...

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December 05, 2022

GcMAF phagocytic activity

2nd Generation GcMAF and Oral MAF both have high phagocytic activity.We regularly test GcMAF activity at Tokushima university a...

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July 10, 2025

Saisei Mirai Featured in Science Featured – Telomere Research Recognized

Dr. Inui’s research on telomere length and aging has been featured in Science Featured, recognizing Saisei Mirai’s contribution...

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February 09, 2025

Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice

Our new article!Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice ...

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December 03, 2024

The Effects of Dietary Intervention and Macrophage-Activating Factor Supplementation on Cognitive Function in Elderly Users of Outpatient Rehabilitation

Abstract Background: Age, genetic, and environmental factors are noted to contribute to dementia risk. Neuroplasticity, protec...

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December 03, 2024

Degalactosylated Whey Protein Suppresses Inflammatory Responses Induced by Lipopolysaccharide in Mice

Abstract The effects of degalactosylated whey protein on lipopolysaccharide (LPS)-induced inflammatory responses in mice were o...

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December 03, 2024

Effect of degalactosylated bovine glycoprotein formulations MAF and M сapsules on lymphopenia and clinical outcomes in hospitalized COVID-19 patients: a randomized clinical trial

Abstract Background Targeting mucosal immunity of the gut, which is known to provide antigen processing, while avoiding excess...

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December 03, 2024

Adjunctive use of oral MAF is associated with no disease progression or mortality in hospitalized patients with COVID-19 pneumonia: The single-arm COral-MAF1 prospective trial☆

Abstract Based on a growing body of evidence that a dysregulated innate immune response mediated by monocytes/macrophages pla...

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August 10, 2023

The Effect of MAF Capsules and M Capsules on Lymphopenia and Clinical Outcomes in Non-Critical Hospitalized COVID-19 Patients

The Effect of MAF Capsules and M Capsules on Lymphopenia and Clinical Outcomes in Non-Critical Hospitalized COVID-19 Patien...

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