How is GcMAF used?

- Anti-aging - Longevity
- Cancer
- Autism
- Infectious diseases
- Skin rejuvenation
- Hair regrowth
- Allergies
- Chronic fatigue syndrome (CFS)
- Multiple sclerosis (MS)
- Rheumatoid arthritis (RA)
- Leaky Gut Syndrome

Our hypothesis of GcMAF and Oral MAF

When a person’s immunity is weak, it takes longer to recover from mental and physical exhaustion and feelings of tiredness remain. Immunity is also affected by stress and tiredness.

How can GcMAF promote anti-aging?

Our hypothesis of GcMAF and Oral MAF is that they could increase the number of young stem cells of macrophages in the blood and tissues, and they could work for the rejuvenation of each tissue, having young and active innate cellular immunity.

3 types of GcMAF

- 1st Generation GcMAF
- 2nd Generation GcMAF (High dose injection) -Saisei Mirai
- 3rd Generation GcMAF (Oral GcMAF) - Saisei Mirai
Saisei Hawaii sells the 3rd Generation GcMAF products. 3 types of GcMAF have been developed in Japan since the development of the first generation GcMAF in 1991. Saisei Mirai developed the 2nd and the 3rd Generation GcMAF. First-generation GcMAF was developed by Dr Yamamoto in 1991. This was Dr Yamamoto’s achievement, accomplished in collaboration with Tokushima University. However, we do not use first-generation GcMAF for clinical applications in Japan anymore because of its low concentration, low stability, and risk of cross-contamination, especially when the vitamin D3 affinity column is used repeatedly. Second-generation GcMAF was developed by Saisei Mirai and Tokushima University in 2010. The advantages of second-generation GcMAF are high concentration (1500 ng/0.5 ml per dose) and significantly high higher stability and macrophage-activating capability. Third-generation GcMAF was developed by Saisei Mirai and Tokushima University in 2014. It is derived from milk protein. A 1-mg capsule has activity equivalent to that of 100-ng purified GcMAF. An enteric (acid-resistant) capsule is used for oral administration to target the Peyer’s patches in the gut. Powder-form oral MAF is used for sublingual administration in the mouth.

Third-generation GcMAF (Oral GcMAF)

We now have 3 forms of Oral MAF – enteric acid-resistant capsules, candy and powder.

Where does Oral MAF target?

MALT (Mucosa-Associated Lymphoid Tissue) constitutes the most extensive part of the human lymphoid tissue. The components of MALT are subdivided into GALT (Gut-Associated Lymphoid Tissue), BALT (Bronchus-Associated Lymphoid Tissue), Waldeyer's tonsillar ring and so on. These are the largest macrophage pool in the body. Many diseases are connected to MALT. Oral MAF is aimed at directly activating the huge number of macrophages in these sites.

Is Oral MAF beneficial for Gut Immunity and Leaky Gut Syndrome?

Yes, Oral MAF is very important. Gut bacteria have an intricate relationship with our immune system and they play a critical role in training immune cells. The gut is surrounded by the largest concentration of immune tissues in the body. An increase in the permeability of the gut lining, and an imbalance in the gut flora, have powerful impacts on the immune system. So this is why oral MAF is very important. Gut Immunity and Leaky Gut Syndrome are also considered to be connected to Autism and Autoimmune diseases.