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Home › What is GcMAF?

MAF – The Ultimate Breakthrogh In Antiaging and Longevity.​

GcMAF (Gc Macrophage Activating Factor) is available in different forms, improving over time for better safety and effectiveness. All our products are developed by Saisei and hold patents globally.​

Dietary MAF not only activates macrophages but also supports cellularrejuvenation.

Studies in mice have shown telomere elongation, increased telomerase (TERT and TERC) expression, and enhanced Klotho gene activity, promoting a more youthful state.​

SAISEI HAWAII USA

Anti-aging and longevity​

Experience the groundbreaking innovation in anti-aging science with Dietary MAF—the only clinically proven solution to extend telomeres by an extraordinary 23% within just six months. Carefully developed by Saisei Pharma, these products are designed not only to enhance your health and appearance but to help you achieve the remarkable goals of looking 20 years younger and living vibrantly well past a century.

Aging is a natural part of life, yet our understanding of it has advanced significantly. Today, there are effective ways to slow this process. Central to these developments are macrophages, vital cells that play a key role in strengthening the immune system and eliminating damaged or unhealthy cells. These remarkable cells contribute to essential functions such as tissue repair, rejuvenation, and regeneration. They also provide robust protection against infections and unchecked tumor growth.

Dietary MAF harnesses cutting-edge science to challenge the inevitability of aging, fostering a life filled with vitality and resilience. Its efficacy is underscored by detailed analyses, including studies on the impact of MAF capsules on telomere length, which have demonstrated remarkable outcomes.

Analysis of the effect of taking MAF capsules on telomere length changes​

SAISEI HAWAII USA


Aging has long been considered inevitable—but scientific advances now suggest it can be slowed, halted, or even reversed. MAF Triple, a next-generation Macrophage Activating Factor (MAF) supplement, plays a crucial role in immune optimization, cellular rejuvenation, and longevity support.

New research into DNA methylation, telomeres, and epigenetic aging clocks is redefining our understanding of aging. These insights confirm that biological age matters more than chronological age, and with the right interventions—such as MAF Triple
—we can actively extend healthspan and reverse cellular aging.

SAISEI HAWAII USA

MAF Boosts Longevity Protein α-Klotho!

A groundbreaking experiment by Dr. Katuura (formerly Kagoshima University, now at Saisei Mirai) showed that dietary MAF significantly increased α-Klotho levels in mice.

✅ Plasma α-Klotho levels: Nearly doubled compared to water and whey protein groups.
✅ Brain (Hypothalamus & Amygdala): Markedly increased α-Klotho content.
✅ Kidney: Strongest α-Klotho increase—vital since kidneys produce ~80% of circulating α-Klotho.

8-day test | 60 μg/ml whey protein in water | Measured via ELISA

This research highlights MAF’s powerful potential in supporting anti-aging and longevity.


SAISEI HAWAII USA

Unlocking the Secrets of Telomeres & Aging​

Degalactosylated Whey Protein (D-WP) Study – Effects on Telomere Length in Mice

A separate experimental study examined the effects of D-WP on telomere length and telomerase gene expression in young and aged mice.

📌 Findings:

✔ D-WP increased telomere length by 154% in young mice, while regular whey protein (WP) showed only a 121% increase.

✔ D-WP significantly upregulated telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) gene expression in peripheral blood.

✔ In aged mice, D-WP restored telomere length to youthful levels.

📌 Implication: D-WP, a key component in MAF Triple, enhances telomere maintenance, supporting longevity and cellular health.

🔗 Access the full study: Scientific Reports (2024)
SAISEI HAWAII USA

Phase 2 Clinical Trial in Japan

📌 Study Objective: Evaluating the efficacy of Dietary MAF for rejuvenation and longevity

📌Number of Participants: 161Telomere length increased by 23% at 6 monthsBiological age reduction observed within 6 months of MAF Triple intake

🔬 Ongoing Research: A similar clinical trial is currently being conducted in Indonesia to further evaluate MAF Triple's rejuvenation and longevity effects.

SAISEI HAWAII USA

Can Telomere Elongation Slow Aging?​


Our latest research shows that MAF Triple has demonstrated telomere elongation in mice. Telomeres, the protective caps at the ends of chromosomes, shorten with each cell division, leading to aging and age-related diseases.

SAISEI HAWAII USA

The Science of Aging – How Does It Work?

Aging isn’t just about time—it’s a biological process driven by molecular changes, particularly:
📌 Telomere Shortening – Limits cell division, leading to tissue degeneration and organ decline. 
📌DNA Methylation Alterations – Epigenetic changes that influence gene activity, driving aging and disease.
📌Oxidative Stress & Chronic Inflammation – Accelerate cellular damage and tissue aging.

SAISEI HAWAII

Address:
1600 Kapiolani Blvd. STE 1328
Honolulu, HI 96814 United States

Phone:
808.452.4908

This phone number is for shipping inquiries only.

For any other questions, please reach out to us through our contact form. We appreciate your understanding.

Important Notice: We do not provide medical treatment or operate a clinic in the United States, including Hawaii.

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LEGAL DISCLAIMER

Statements made, or products sold through this website, have not been evaluated by the United States Food and Drug Administration (FDA). They are not intended to diagnose, treat, cure or prevent any disease.

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